By A. F. List, C. M. Spier, W. S. Dalton (auth.), Prof. Dr. W. Hiddemann, Prof. Dr. T. Büchner, Priv. Doz. Dr. B. Wörmann, Prof. Dr. W. Plunkett, Prof. Dr. M. Keating, Prof. Dr. M. Andreeff (eds.)

ISBN-10: 3540539492

ISBN-13: 9783540539490

ISBN-10: 3642765912

ISBN-13: 9783642765919

This can be the 3rd quantity during this sequence on tools of treating acute leukemia. a number of drug resistance is mentioned, besides using human granulocyte-macrophage CSF, the position of stem mobilephone issue, and simple elements of mobilephone biology and pharmakokinetics. there's additionally a entire part facing relapse treatment and postremission remedy. The e-book hence offers the clinician with guidance to be used in daily perform.

Show description

Read or Download Acute Leukemias: Pharmacokinetics and Management of Relapsed and Refractory Disease PDF

Similar management books

Read e-book online Handbook of Public Administration PDF

The previous 20 years were marked via a interval of considerable, and infrequently primary, swap in public management.

This significant new overseas instruction manual presents a whole assessment and consultant to prior and current wisdom during this crucial box of inquiry. Assembling a great crew of students from all over the world, it comprehensively explores the present state-of-the-art in educational pondering and the present buildings and techniques for the management of public coverage following this era of fast transformation and alter.

A dominant subject matter during the guide is a serious mirrored image at the application of scholarly concept and the level to which govt practices tell the advance of this thought. To this finish it serves as a necessary consultant for either the perform of public management this day and its on-going improvement as an instructional self-discipline.

A significant landmark e-book, the instruction manual of Public management should be vital to the educating, examine and perform of public management for college kids, lecturers and pros far and wide.

First overseas guide to map the self-discipline following a interval of big transformation and reform - B man Peters

Read e-book online Declarative Programming for Knowledge Management: 16th PDF

Wisdom potential strength – yet provided that it truly is on hand on the correct time, the suitable position, and within the arms of the fitting humans. based, engineered, repeatable methodsto gather,transport,andapplyknowledgearecollectivelycalledkno- aspect administration. Declarative programming strives for the perfect of programming through want: the consumer states what she or he wishes, and the pc ?

Download e-book for iPad: The Management of Non-Hodgkin’s Lymphomas in Europe by Silvio Monfardini (auth.), Silvio Monfardini (eds.)

The ecu college of Oncology got here into lifestyles to reply to a necessity for informa­ tion, schooling and coaching within the box of the prognosis and therapy of melanoma. There are major explanation why such an initiative was once necessary. to start with, the instructing of oncology calls for a conscientiously multidisciplinary strategy that is tricky for the Univer­ sities to place into perform when you consider that their approach is principally disciplinary oriented.

Extra info for Acute Leukemias: Pharmacokinetics and Management of Relapsed and Refractory Disease

Sample text

We recently examined the possibility that the dose schedule of MTX employed may influence the type of resistance obtained. M), and following regrowth, cells were repeatedly exposed to this drug in this same schedule. After 6-7 cycles of exposure, cell growth was no longer significantly affected by this dose of drug. The mechanism of resistance found in these cell lines (CCRF-CEM R 3/7 and CCRF-CEM R 30/6) was impaired polyglutamylation [27]. Of great interest was that relative sensitivity of these cell lines to continuous exposure (for 72 h) of MTX was essentially unchanged.

Bertino was supported by American Cancer Society Grant #BE-40F. 16 understanding of mechanisms of intrinsic resistance to MTX. Mechanisms of Acquired Resistance to MTX MTX is an excellent model drug for the study of resistance. The major target for the drug is known (dihydrofolate reductase, DHFR) , and cell lines have been developed with acquired resistance to the drug both from animal and human tumors that show one or more different mechanisms of resistance: decreased influx (decreased V MAX or K,), increased DHFR, altered DHFR that binds MTX less tightly than the wild-type enzyme, or decreased retention due to decreased polyglutamylation (reviewed in [3]).

R. Bertino was supported by American Cancer Society Grant #BE-40F. 16 understanding of mechanisms of intrinsic resistance to MTX. Mechanisms of Acquired Resistance to MTX MTX is an excellent model drug for the study of resistance. The major target for the drug is known (dihydrofolate reductase, DHFR) , and cell lines have been developed with acquired resistance to the drug both from animal and human tumors that show one or more different mechanisms of resistance: decreased influx (decreased V MAX or K,), increased DHFR, altered DHFR that binds MTX less tightly than the wild-type enzyme, or decreased retention due to decreased polyglutamylation (reviewed in [3]).

Download PDF sample

Acute Leukemias: Pharmacokinetics and Management of Relapsed and Refractory Disease by A. F. List, C. M. Spier, W. S. Dalton (auth.), Prof. Dr. W. Hiddemann, Prof. Dr. T. Büchner, Priv. Doz. Dr. B. Wörmann, Prof. Dr. W. Plunkett, Prof. Dr. M. Keating, Prof. Dr. M. Andreeff (eds.)


by Donald
4.3

Rated 4.20 of 5 – based on 30 votes